Another PLOS One paper, another malaria paper, another paper from Tanzania, another paper on women's health. I might branch out at some point. Or I might not. It's an exciting time for malaria research in Africa, so there's lots of new stuff coming out.
Malaria in pregnancy is a huge public health problem, with tremendous implications for fetal development as well as maternal health, and every bit of knowledge that we can use in its treatment is vital. Like this paper, looking at combo anti-malarials versus monotherapy, where the researchers randomized pregnant women with mild falciparum malaria to four different treatment regimens and looked therapy failure after four weeks. Knowledge of local resistance patterns is crucial in understanding the implications of the study - these lessons can't necessarily be applied in Asia or Central America, for example, or can't necessarily be applied 5-10 years from now in Tanzania itself. That's why we constantly need studies like this, to prove that we're still doing the right thing when treating this constantly adapting illness, trying to stay one step ahead while prevention efforts continue (see prior blog post).
Beyond the main finding of the combination of anti-malarials being effective, while its two components are individually ineffective, the finding of differing efficacy between study subjects and children reinforces the idea of partial immunity being helpful in fighting off the disease. Children likey need completey different, more intensive, typically artemensin-based, regimens compared to adults in the same community, a striking idea that may be unique to malaria treatment in the world of infectious diseases.
Ref: Mutabingwa TK, Muze K, Ord R, Briceño M, Greenwood BM, et al. (2009) Randomized Trial of Artesunate+Amodiaquine, Sulfadoxine-Pyrimethamine+Amodiaquine, Chlorproguanal-Dapsone and SP for Malaria in Pregnancy in Tanzania. PLoS ONE 4(4): e5138. doi:10.1371/journal.pone.0005138
Subscribe to:
Post Comments (Atom)
likey need completey
ReplyDeletesllepcchek?
ReplyDeleteIt took almost one year for my first real outbreak but it was the hardest thing in the world to get along with. I felt so unwanted and dirty. I tried many formulas, suggestions, methods to get rid of it permanently. Booked appointment with many doctors, professionals, even religiously until I started getting away spiritually and still it won't go. The worst is my outbreaks occurs within short period and take as long as even weeks to go away. I was at last placed on antiviral treatment which is a good treatment but for how long? I prayed every four times a day for God to cure me miraculously or direct me to cure because I know there is. During outbreaks I thought it's the end of the world but it's not, with time I will become normal again. I started trying fruits and herbs, take herbal produced, and with time became very interested in herbs. I read blogs, websites, and comments on herbs and built a stronger hope. I saw comments and decided to try Dr Utu African Traditional Herbal meds. I know of one mr Brown who was HIV and now brags he was cured of HIV with Dr Utu traditional meds but never give it a thought because I believed HIV already has a cure and never think it through or make a research. And for herpes my doctor told me that there is no known cure. When I saw testimonies of his Herpes cure on sites. I copied his contact drutuherbalcure@gmail.com. I showed it to brown who confirmed it was Dr Utu contact. I contacted him immediately and he also prepared and sent me herbal herpes meds through DHL. Right after getting this traditional meds I followed the prescription cautiously and withing days I started noticing rapid change and I know within me it's the cure. I used it for up to two weeks and when my test result was out not only did this herbal meds cure me but boost my immune and I feel real and free. Dr Utu African Traditional meds have successfully cured Herpes, Warts, HIV, Cancers, Kidney Stone, Asthma, most importantly this traditional meds boost immune and have no after effect.