Saturday, January 30, 2010

HIV and Herpes, together forever

What we know, in terms of herpes and HIV, and everybody can mostly agree upon:
1) Co-infection with herpes simplex virus increases the risk of transmission of HIV, mostly
from the decreased mucosal damage from herpes ulcers.
2) Acyclovir, our preferred antiviral for herpes simplex, reduces HSV levels in blood.
3) Acyclovir also has effects on HIV, with both in vitro and in vivo activity, either indirectly through HSV or directly on HIV replication itself.
4)
An exacerbation of HSV is associated with worsening HIV disease.

So, it makes sense that co-infected people who are on acyclovir, take it well, and get subsequent suppression of their herpes would have lower transmissibility of their HIV. Unfortunately, as this trial in this week's New England Journal of Medicine shows, this isn't the case.

It's probably the best-done, largest study that can be done looking at the issue, effectively closing the door on being able to reduce HIV transmission solely through HSV treatment. Finding 3400 willing couples where one partner is HIV and HSV positive and the other is negative for both must have been incredibly difficult. Also, the strict, but necessary, inclusion criteria, such as not yet being on antiretroviral treatment and being otherwise well, must have limited recruitment.

In the end, they reduced blood HIV levels and the incidence of genital ulcers, but, sadly, couldn't reduce HIV transmission, their primary outcome. The ultimate goal of bringing down HIV blood levels, through antiretrovirals or the treatment of other concomitant infections and illnesses, might use acyclovir as part of a multi-factorial approach. By itself, however, it doesn't seem to work, at least to the degree hoped for.

One point is that those enrolled in the study received fairly intensive counseling regarding safe sexual practices for serodiscordant couples, meaning that the overall transmission rate was lower than for the general population, increasing the numbers needed to find a difference in transmission rate. Everybody, however, should be receiving this support, and that can't be taken as a criticism of the study itself. In addition, almost 30% of the new infections in the study were with different viruses than their partners, meaning they were infected by somebody else's virus, reinforcing the need for effective counselling and support.

In the end, managing serodiscordant couples will continue to be a challenge, and will likely involve more aggressive use of antiretrovirals and counselling, similar to that in this study.



Celum, C., Wald, A., Lingappa, J., Magaret, A., Wang, R., Mugo, N., Mujugira, A., Baeten, J., Mullins, J., Hughes, J., Bukusi, E., Cohen, C., Katabira, E., Ronald, A., Kiarie, J., Farquhar, C., Stewart, G., Makhema, J., Essex, M., Were, E., Fife, K., de Bruyn, G., Gray, G., McIntyre, J., Manongi, R., Kapiga, S., Coetzee, D., Allen, S., Inambao, M., Kayitenkore, K., Karita, E., Kanweka, W., Delany, S., Rees, H., Vwalika, B., Stevens, W., Campbell, M., Thomas, K., Coombs, R., Morrow, R., Whittington, W., McElrath, M., Barnes, L., Ridzon, R., Corey, L., & , . (2010). Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2 New England Journal of Medicine DOI: 10.1056/NEJMoa0904849

12 comments:

  1. Thank you for the post. We really need to be careful all the time. I am diagnose with herpes, it was so uncomfortable the blisters and not to mention the pain. Good thing I have Zovirax stocked on my cabinet. It lessens the discomfort and stops the infection from spreading or worsening. Plus it is safe to take even when pregnant. And when breastfeeding do not take this drug! You can see the complete drug info and other meds at http://medsheaven.com/index.html

    ReplyDelete
  2. It looks like the cheap aciclovir herpes pill may be The HIV Pill (thehivpill.com), capable of reducing the risk of HIV progression by 16%. Research involving 3,300 patients in Africa was just reported in the prestigious medical journal The Lancet. In addition to giving new value to the domain thehivpill.com, this news also shows the value of the domain AtHomeHIVtest.com and HIVabzymes.com. (Researchers at the University of Texas Medical School in Houston in 2008 announced they found a way to fight HIV by altering the part of its genetic code than never mutates. They used monoclonal antibodies known as abzymes, which are naturally produced in the human body.) Buy any of these domains by submitting your offer as a "comment" at http://domaineer.blogspot.com/2010/02/hiv-pill-thehivpillcom.html

    ReplyDelete

  3. Greetings to the general public,i want to inform the
    public how i was cured of HERPES Simplex Virus by a Doctor called
    astogo.i visited different hospital but they gave me list of drugs
    like Famvir, Zovirax, and Valtrex which is very expensive to treat the
    symptoms and never cured me. I was browsing through the Internet
    searching for remedy on HERPES and i saw comment of people talking about
    how Doctor astogo cured them. when i contacted him he gave me hope and send a
    Herbal medicine to me that i took and it seriously worked for me, am a
    free person now without problem, my HERPES result came out negative. I
    pray for you Dr astogo God will give you everlasting life, you shall
    not die before your time for being a sincere and great men. Am so happy,
    you can also contact him if you have any problem Email: drastogospellhome@gmail.com.
    or call him on +2348104933655.

    ReplyDelete
  4. Greetings to the general public, i want to inform the public how i was cured of HERPES Simplex Virus by a Doctor called Dr West. i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how Doctor West cured them. I Was scared because i never believed in the Internet but i was convince to give him a try because i was having no hope of been cured of HERPES so i decided to contact him on his email that was listed on the comment (dr.kakuduwesthealingtemple@outlook.com ) i searched his email on net and i saw a lot of people testifying about his goodness. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without problem, my HERPES result came out negative. I pray for you Dr West God will give you everlasting life, you shall not die before your time for being a sincere and great man. Am so happy, you can also contact him if you have any problem Email: dr.kakuduwesthealingtemple@outlook.com

    DOCTOR WEST CAN AS WELL CURE THE FOLLOWING DISEASE:-

    1. HIV/AIDS
    2. HERPES
    3. CANCER
    4. ALS

    ReplyDelete

  5. This is real take it serious, who will believe that a herb can cure herpes, i never believe that this will work i have spend a lot when getting drugs from the hospital to keep me healthy, what i was waiting for is death because i was broke, one day i hard about this great man who is well know of HIV and cancer cure, i decided to email him, unknowingly to me that this will be the end of the herpes in my body, he prepare the herb for me, and give me instruction on how to take it, at the end of the one month, he told me to go to the hospital for a check up, and i went, surprisingly after the test the doctor confirm me negative, i thought it was a joke, i went to other hospital was also negative, then i took my friend who was also suffering from herpes to the Dr OLUKU, after the treatment she was also confirm herpes free . He also have the herb to cure cancer. please i want every one with this virus to be free, that is why am dropping his email address, drolukuspellhome@gmail.com do email him he is a great man. the government is also interested in this DR, thank you for saving my life, and I promise I will always testify for your good work.

    ReplyDelete
  6. Hello Reader
    My Name is, Natasha Johnson
    my ex-boyfriend dumped me 4 months ago after I caught
    him of having an affair with someone else and insulting him.
    I want him back in my life but he refuse to have any contact
    with me. I was so confuse and don’t know what to do, so I
    visited the internet for help and I saw a testimony on how a
    spell caster (Dr Okpebho) help them to get their ex back so I
    contact the spell caster (Dr Okpebho) and i explain all my
    problems to him….. he cast a spell for me and assure me of
    2days that my ex will lover will return to me and to my greatest
    surprise the second day my boyfriend came knocking on my
    door and beg for forgiveness. I am so happy that my love is
    back again and not only that, we are about to get married.
    Once again thank you for helping me to get my love back
    and your love spell is truly indeed perfect, you are truly talented
    and gifted i will continue to publish your name on the net
    , Dr Okpebho because of the good work you are doing. If you need his help
    contact him now through his email:
    Drokpebhospelltemple@gmail.com He is also specialize on all kind of
    spell and herbs such as:
    1 LOVE SPELL
    2 WIN EX BACK
    3 FRUIT OF THE WOMB
    4 PROMOTION SPELL
    5 PROTECTION SPELL
    6 BUSINESS SPELL
    7 GOOD JOB SPELL
    8 LOTTERY SPELL
    9 CURE HERPES
    10 CURE HIV/AIDS
    11 CANCER OF ANY TYPE
    12 HEPATITIS B AND C
    YOU CAN CONTACT HIM NOW AND GET YOUR PROBLEM
    SOLVED email: Drokpebhospelltemple@gmail.com

    ReplyDelete


  7. God bless Dr. Temi for his marvelous work in my life, I was diagnosed of HERPES since 2012 and I was taking my medications, I wasn't satisfied i needed to get the HERPES out of my system, I searched about some possible cure for HERPES i saw a comment about Dr. Temi, how he cured HERPES with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine through UPS SPEED POST. I took the medicine as prescribed by him and 14 days later i was cured from HERPES, Dr. Temi truly you are great, do you need his help also? Why don't you contact him through doctortemiherbalhome@gmail.com whatsapp him on +2348112252378

    DOCTOR TEMI CAN AS WELL CURE THE FOLLOWING DISEASE:-

    1. HIV/AIDS
    2. HERPES
    3. CANCER
    4. ALS

    ReplyDelete


  8. God bless Dr. Temi for his marvelous work in my life, I was diagnosed of HERPES since 2012 and I was taking my medications, I wasn't satisfied i needed to get the HERPES out of my system, I searched about some possible cure for HERPES i saw a comment about Dr. Temi, how he cured HERPES with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine through UPS SPEED POST. I took the medicine as prescribed by him and 14 days later i was cured from HERPES, Dr. Temi truly you are great, do you need his help also? Why don't you contact him through doctortemiherbalhome@gmail.com whatsapp him on +2348112252378

    DOCTOR TEMI CAN AS WELL CURE THE FOLLOWING DISEASE:-

    1. HIV/AIDS
    2. HERPES
    3. CANCER
    4. ALS

    ReplyDelete
  9. Hello Everyone,I want to share my testimonies to the general public on how this great man called DR.MOMOH who
    cure my herpes simplex virus, I have been a HERPES patient for over 9 Months and i have
    been in pains until i came across this lady when i traveled for
    Business trip who happen to once been a herpes patient, i explained every
    thing to her and she told me that there is this Great man that help her to
    cure her herpes and she gave me his email address for me to contact and i did as she instructed. And the man DR.MOMOH told me how much to buy the
    herpes herbal medication and how i will get it, which i did. And to my
    greatest surprise that i took the Herpes herbal medicine for just one week
    and behold i went for a herpes test, for to my greatest surprise for the
    Doctor confirmed me to herpes free and said that i no longer have
    herpes in my system and till now i have never felt any pains nor herpes again, so i
    said i must testify the goodness of this man to the general public for if
    you are there surfing from this Herpes problems or any deadly disease or
    other disease for i will advice you to contact him on his working
    email: drmomohherbalcenter@gmail.com and i assure you that he will help
    you just as he did for me okay
    contact him on his email: drmomohherbalcenter@gmail.com his cell phone number +2347051839672
    THESE ARE THE THINGS DR MOMOH DOES
    1. HERPES
    2. HEPATITIS
    3. LASSA FEVER
    4. GONORRHEA
    5. HIV/AIDS
    6. LOW SPERM COUNT
    7. MENOPAUSE DISEASE
    8. EPILEPSY
    9. A SEPSIS
    10.CANCER
    11.ANXIETY DEPRESSION

    ReplyDelete
  10. I can’t believe this. A great testimony that i must share to all HERPES
    SIMPLEX VIRUS patient in the world i never believed that their could be any
    complete cure for Herpes or any cure for herpes,i saw people’s testimony on
    blog sites of how Dr Waziri prepare herbal cure and brought them back to
    life again. i had to try it too and you can,t believe that in just few
    weeks i started using it all my pains stop gradually and i had to leave
    without the herpes the doctor gave to me. Right now i can tell you that few
    months now i have not had any pain,delay in treatment leads to death. Here
    is his email:drwaziriherbalhome@gmail.com

    ReplyDelete
  11. Am Judymay Bourbon. I have been suffering from (HERPES) disease for
    the past four years and had constant pain, especially in my knees.
    During the first year,I had faith in God that i would be healed
    someday.This disease started circulate all over my body and i have
    been taking treatment from my doctor, few weeks ago i came on search
    on the internet if i could get any information concerning the
    prevention of this disease, on my search i saw a testimony of someone
    who has been healed from (Hepatitis B and Cancer) by this Man Dr
    IDEMUDIAN and she also gave the email address of this man and advise
    we should contact him for any sickness that he would be of help, so i
    wrote to Dr IDEMUDIAN telling him about my (HERPES Virus) he told me
    not to worry that i was going to be cured!! hmm i never believed it,,
    well after all the procedures and remedy given to me by this man few
    weeks later i started experiencing changes all over me as the Dr
    assured me that i have cured,after some time i went to my doctor to
    confirmed if i have be finally healed behold it was TRUE, So friends
    my advise is if you have such sickness or any other at all you can
    email Dr IDEMUDIAN on; (dridemudian@gmail.com ) or call +2348068540264
    for assistance. sir i am indeed grateful for the help i will forever
    recommend you to my friends!

    ReplyDelete
  12. I am Frank from New York. I was in trouble when doctor told me that I have been diagnosed with Genital Herpes... I thought about my Family, I know my Family will face a serious problem when I'm gone, I lost hope and I wept all day, but one day I was searching the internet I found Dr. Ekpiku's contact number. I called him and he guided me. I asked him for solutions and he started the remedies for my health. Thank God, now everything is fine, I'm cured by Dr. Ekpiku herbal medicine, I'm very thankful to Dr. Ekpiku and very happy with my hubby and family. email him on ekpikuspelhomeofgrace@gmail.com or ekpikuspelhomeofgrace@hotmail.com call +2348073673757 OR whatsup him OR http://ekpikuspellhomeofgrace.blogspot.com/ THESE ARE THE THINGS Dr. Ekpiku. HERPES. HIV/AIDS. CANCER. ALS .

    ReplyDelete