Saturday, April 24, 2010

Mining for malaria cures

Malaria, as I've written about many times before, kills for reasons that we're not completely sure of yet. We give medications that work directly against the parasite itself, but oftentimes it's insufficient, and people die due to their body's inflammatory response to the invading parasite. Predicting, early on, who will die, and what we can do about it, is an active field of research, with some innovative discoveries over the past few years.

Adding to this is a mouse study looking at charcoal in the treatment of malaria. Oral charcoal doesn't get absorbed through your gut and has been safely used for years for adsorbing ingested toxins; it also has been shown to be an anti-inflammatory through unconfirmed mechanisms. It may be able to adsorb any intestinally-mediated toxins, as well as cytokines from the blood through a mechanism that I don't completely understand. Regardless of mechanism, these investigators randomized mice experimentally infected with malaria to oral charcoal or not, and the results were striking. All untreated mice died and only 55% of treated mice died. They reconfirmed their results with just the charcoal itself, and not its diluent - this time none of the untreated mice survived and 60% of the treated mice survived at day 10.

Mechanistically, there seems to be a moderate effect on the production of inflammatory cytokines, specifically by various T-cell lineages. They also looked at whole blood global gene expression analysis and found a significantly different profile amongst the treated mice, one that more closely resembled uninfected mice. Most importantly, they also wisely included a phase I human study, seeing if charcoal had any effects on the pharmacokinetics of antimalarials, one of the main concerns of this potential treatment (antimalarial overdose is often treated with activated charcoal, for example). It didn't have any effect on drug levels, but they used intravenous antimalarials - it remains to be seen if it is safe with administered with the more commonly given oral antimalarials.

Like they mention in their discussion, charcoal can never be used as a stand-alone therapy. As an adjunct in severe cases, it holds promise, given its safety and affordability. More importantly, understanding its molecular mechanism of activity in using the gut to reduce systemic inflammation in the malarial response could yield many other avenues of research. Human trials will need to happen, and I'm skeptical as to whether or not it can be given with oral medications, but a valuable addition to the adjunctive therapy in malaria literature.


de Souza, J., Okomo, U., Alexander, N., Aziz, N., Owens, B., Kaur, H., Jasseh, M., Muangnoicharoen, S., Sumariwalla, P., Warhurst, D., Ward, S., Conway, D., Ulloa, L., Tracey, K., Foxwell, B., Kaye, P., & Walther, M. (2010). Oral Activated Charcoal Prevents Experimental Cerebral Malaria in Mice and in a Randomized Controlled Clinical Trial in Man Did Not Interfere with the Pharmacokinetics of Parenteral Artesunate PLoS ONE, 5 (4) DOI: 10.1371/journal.pone.0009867

11 comments:

  1. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
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    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  2. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  3. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  4. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  5. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  6. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  7. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  8. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  9. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  10. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete