Saturday, April 24, 2010

Mining for malaria cures

Malaria, as I've written about many times before, kills for reasons that we're not completely sure of yet. We give medications that work directly against the parasite itself, but oftentimes it's insufficient, and people die due to their body's inflammatory response to the invading parasite. Predicting, early on, who will die, and what we can do about it, is an active field of research, with some innovative discoveries over the past few years.

Adding to this is a mouse study looking at charcoal in the treatment of malaria. Oral charcoal doesn't get absorbed through your gut and has been safely used for years for adsorbing ingested toxins; it also has been shown to be an anti-inflammatory through unconfirmed mechanisms. It may be able to adsorb any intestinally-mediated toxins, as well as cytokines from the blood through a mechanism that I don't completely understand. Regardless of mechanism, these investigators randomized mice experimentally infected with malaria to oral charcoal or not, and the results were striking. All untreated mice died and only 55% of treated mice died. They reconfirmed their results with just the charcoal itself, and not its diluent - this time none of the untreated mice survived and 60% of the treated mice survived at day 10.

Mechanistically, there seems to be a moderate effect on the production of inflammatory cytokines, specifically by various T-cell lineages. They also looked at whole blood global gene expression analysis and found a significantly different profile amongst the treated mice, one that more closely resembled uninfected mice. Most importantly, they also wisely included a phase I human study, seeing if charcoal had any effects on the pharmacokinetics of antimalarials, one of the main concerns of this potential treatment (antimalarial overdose is often treated with activated charcoal, for example). It didn't have any effect on drug levels, but they used intravenous antimalarials - it remains to be seen if it is safe with administered with the more commonly given oral antimalarials.

Like they mention in their discussion, charcoal can never be used as a stand-alone therapy. As an adjunct in severe cases, it holds promise, given its safety and affordability. More importantly, understanding its molecular mechanism of activity in using the gut to reduce systemic inflammation in the malarial response could yield many other avenues of research. Human trials will need to happen, and I'm skeptical as to whether or not it can be given with oral medications, but a valuable addition to the adjunctive therapy in malaria literature.


de Souza, J., Okomo, U., Alexander, N., Aziz, N., Owens, B., Kaur, H., Jasseh, M., Muangnoicharoen, S., Sumariwalla, P., Warhurst, D., Ward, S., Conway, D., Ulloa, L., Tracey, K., Foxwell, B., Kaye, P., & Walther, M. (2010). Oral Activated Charcoal Prevents Experimental Cerebral Malaria in Mice and in a Randomized Controlled Clinical Trial in Man Did Not Interfere with the Pharmacokinetics of Parenteral Artesunate PLoS ONE, 5 (4) DOI: 10.1371/journal.pone.0009867

15 comments:

  1. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  2. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  3. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  4. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  5. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  6. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  7. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  8. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  9. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  10. jenny

    i want to thanks doctor bolala for the marvelous work he did in my life, i have been suffering herpes for three years now, and i have applied various medical drugs but they were all in vain,i have been treated in different medical hospital but my condition remains the same till i finally concluded that there were no cure to my illness, i was searching through the internet when i saw a comment by jane on how she was cured by doctorbolala and she stated in her comment that ever since she had been cure that she had never had any outbreak so i don't believe her because i believe there was no cure to it.but i decided to contact the doc with the email she dropped, and he replied and ask me few questions about my body , he prepared the herbal cure and send it to me through FedEx and after i have taken it for one week and two days as i was instructed then i went for a test to my greatest surprise my result cam out negative, am so happy right now and if you are suffering of any kind of disease you can contact he on this email: doctorbolala@gmail.com or call:+2348103278165
    he can as well help in the following:
    1]HIV/AID
    3}cancer
    3}HPV
    4}LOVE SPELL
    5}Herpes
    6}SYPHILI

    ReplyDelete
  11. Unfortunately there are a lot of AIDS/Herpes denials on Herbal cures still out there. I did research on them after I was tested HIV/Herpes positive I was so worried am I going to die soon. I continue my search again on herbal remedy for Std, then I found lots of testimony on how Dr Itua Herbal Medicine Cured HIV/Aids, Herpes Virus,Copd, Hepatitis, Diabetes, On websites sharing their testimonies, which made much more sense to me. All the authors pronounce Dr Itua As a man with Good Heart, I pick interest in their testimonies and I contact him about my situation then he gave me procedure how it works, I proceed after one week he courier his Herbal Medicine to me and instruct me on how to drink it for two weeks to cure. I receive His Herbal Medicine so I drank it for two weeks as I was told then after 2 days I go for a test I found out I was cured from HIV/Aids & Herpes Virus, I pay homage to him 2 months ago to his country to celebrate with him on his African festival which he told me it usually happens every year. I know there are lots of (HIV)/Aids&Herpes Virus denials of Herbal Remedy movement the same few doctors and they represent a very small faction of the community. I could have died because I refused Natural Herbs Cures for so long, but luckily, by the grace of God I am alive to tell my story. Contact Info...Whatsapp Number...+2348149277967,Email...drituaherbalcenter@gmail.com/My Instagram Username...avat5634 Just in case you need someone to talk with.

    ReplyDelete

  12. It took almost one year for my first real outbreak but it was the hardest thing in the world to get along with. I felt so unwanted and dirty. I tried many formulas, suggestions, methods to get rid of it permanently. Booked appointment with many doctors, professionals, even religiously until I started getting away spiritually and still it won't go. The worst is my outbreaks occurs within short period and take as long as even weeks to go away. I was at last placed on antiviral treatment which is a good treatment but for how long? I prayed every four times a day for God to cure me miraculously or direct me to cure because I know there is. During outbreaks I thought it's the end of the world but it's not, with time I will become normal again. I started trying fruits and herbs, take herbal produced, and with time became very interested in herbs. I read blogs, websites, and comments on herbs and built a stronger hope. I saw comments and decided to try Dr Utu African Traditional Herbal meds. I know of one mr Brown who was HIV and now brags he was cured of HIV with Dr Utu traditional meds but never give it a thought because I believed HIV already has a cure and never think it through or make a research. And for herpes my doctor told me that there is no known cure. When I saw testimonies of his Herpes cure on sites. I copied his contact drutuherbalcure@gmail.com. I showed it to brown who confirmed it was Dr Utu contact. I contacted him immediately and he also prepared and sent me herbal herpes meds through DHL. Right after getting this traditional meds I followed the prescription cautiously and withing days I started noticing rapid change and I know within me it's the cure. I used it for up to two weeks and when my test result was out not only did this herbal meds cure me but boost my immune and I feel real and free. Dr Utu African Traditional meds have successfully cured Herpes, Warts, HIV, Cancers, Kidney Stone, Asthma, most importantly this traditional meds boost immune and have no after effect.

    ReplyDelete
  13. Herpes is a serious and recurring disease which can't be cured through drugs or injections by an American doctors but the best way to cure Herpes virus is by taking natural herbal mixed medicine for permanent treatment.I'm here to appreciate Dr James for using his herbal medicine to cure my herpes virus. Is about 3 years and 6 months now I have been living with this virus inside of me and it have really really been a serious problem to me, I was so confused because I have been taking several drugs and injections to be cured but all of my effort was in vain, one morning I was browsing the internet then I saw several testimonies about Dr James herbal mix medicine, curing people from herpes virus / HIV AIDS and Immediately I contacted Dr James on his email: drjamesherbalmix@gmail.com. I told him about my problems and he tells me that I must be cured. He gave me instructions which I rightly followed, so he prepared his herbal mixed medicine and sent it to me through UPS SPEED POST, which I used (MORNING AND EVENING) for 2 weeks and I was cured. everything was like a dream to me and my herpes virus was permanently cured. Dr James thank you, if out here suffering from herpes virus or any KIND OF diseases LIKE... HIV/AIDS, DIABETES, CANCER,RECTUM EFFECTS, BOWEL OBSTRUCTION, HERPES, HEPATITIS A&B, CARDIAC DISEASES, CHRONIC DISEASES, YELLOW FEVER, EPILEPSY, LUPUS, STROKE, SPINAL CORD, ECZEMA, KIDNEY DISEASES, ACME, BACK PAIN, DENGUE SCHIZOPHRENIA, APOLLO,MULTIPLES SCLEROSIS, HIGH BLOOD PRESSURE, VAGINAL DISCHARGING, ARTHRITIS, MENINGITIS itchy' contact.Doctor James and be free from your diseases because I am a living testimony, Dr James, is honest herbalist doctor, he is also known as the Great herbal cure master for herbal root. Contact him now via his email: (drjamesherbalmix@gmail.com) (whatsapp or call him on +2348152855846  

    ReplyDelete
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